The Challenge of Understanding Long COVID
El reto de comprender a Long COVID
Authors: Lorena Vigón
Coauthors: Mayte Coiras
Keywords: Long COVID. Immune response. Cytotoxicity. Herpesvirus reactivation
Keywords: Long COVID. Respuesta inmunitaria. Citotoxicidad. Reactivación del herpesvirus
Abstract: Most individuals recover completely after mild infection with SARS-CoV-2, but about 10% of them develop a new syndrome termed Long COVID or PostCOVID condition that shares common characteristics with an autoimmune disease. In this study, we observed significant differences in the immune response developed against SARS-CoV-2 in individuals who recovered completely, in comparison with individuals who developed Long COVID. These individuals showed a defective cytotoxic immune response, which may be related to an impaired viral clearance and may also explain the reactivation of Epstein-Barr virus.
Abstract : La mayorÃa de los individuos se recuperan completamente después de una infección leve por el SARS-CoV-2, pero alrededor del 10% de ellos desarrollan un nuevo sÃndrome denominado COVID largo o condición PostCOVID que comparte caracterÃsticas comunes con una enfermedad autoinmune. En este estudio, observamos diferencias significativas en la respuesta inmunitaria desarrollada contra el SARS-CoV-2 en los individuos que se recuperaron completamente, en comparación con los individuos que desarrollaron COVID largo. Estos individuos mostraron una respuesta inmune citotóxica defectuosa, que puede estar relacionada con una eliminación viral deteriorada y también puede explicar la reactivación del virus de Epstein-Barr.
16-06-2022
Lorena Vigón
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| Citation: Lorena Vigón, Mayte Coiras. El reto de comprender a Long COVID. https://doi.org/10.24175/sbd.2022.000132 |
| Received: June 16, 2022 Accepted: June 16, 2022 Published: June 16, 2022 |
| Copyright: © 2022 Vigón et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY-NC), which allows, distribution, reproduction in any medium, provided the original author and source are credited and non-commercial use. |
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